IMMUNOHISTOCHEMICAL EVALUATION OF VON WILLEBRAND FACTOR IN ENDOTELIUM OF MYOMETRIAL VESSELS IN THE PROJECTION OF UTEROPLACENTAL BED DURING THE IRON DEFICIENCY ANEMIA IN PREGNANCY

Iron deficiency anemia in pregnancy (IDAP) is one of the most pressing problems ofmodern obstetrics, its frequency different regions varies a wide range 28 –85%. Pregnant women with iron undergo gestational immaturityin utero-placental bed due to insufficiency cytotrophoblastic invasion. It knownthat defective rearrangement arteries, especiallytheir myometrial segments, morphological basis for increasing pressure inthe intervillous space. Immunohistochemical technique von Willebrand factor inutero-placental and myometrium allows assess processes angiogenesisand vasculogenesis, endothelial dysfunction, early late thrombosis, features thegestational reorganization spiral arteries bed.Purpose work: determine immunoexpressionin endothelium vessels projection iniron at 37 – 40 weeks gestation.Material methods. 58 biopsies weremorphologically studied after being obtained during caesarean section, observations ofphysiological gestation conditions I - II degree IDAP withoutclinical signs placental insufficiency. On histological sections were performed: 1)immunohistochemical method factor; 2) histochemical forfibrin collagen fibers by NZ Slinchenko; 3) staining hematoxylin eosin.Results. Observations bedduring against background showed significant increase theintensity endotheliocytes all vessel types: optical density was 0.451±0.0024 ODU, conditionsof 0,458±0.0022 ODU; venous Idegree 0,393±0,0026 veins theII 0,405±0,0022 microcirculation degreeimmunoexpression 0,394±0,0022 IDAPof 0,398±0,0025 ODU.Conclusions. During anemia,the have gestationalimmaturity. The growth immunoexpression endothelialcells, manifestation enhanced cell desquamation thrombosis atdifferent stages, detected types vessels, should be regardedas prerequisites hypoperfusion development thedisorders outflow from uterus.